Chronic kidney disease is detected frequently in older cats, reflecting feline renal structure, the heavy load of concentrating urine, and cumulative damage over longer lifespans.

Cats descend from arid-region ancestors and concentrate urine powerfully, keeping the kidneys under high workload so insults accumulate toward decompensation.

Past acute kidney injury, chronic dental inflammation, hypertension, and certain toxins are all considered contributors, with mechanisms still under study.

From about age seven, add kidney bloodwork and urinalysis to annual exams; after diagnosis, follow the vet's diet and medication plan throughout.